EN
2021 Group Stage
Group A
| Pl | W | D | L | Diff | Pts | |||
| 1 | Rosario Central | 6 | 3 | 2 | 1 | 10:3 | 7 | 11 |
| 2 | Huachipato | 6 | 2 | 2 | 2 | 4:10 | -6 | 8 |
| 3 | San Lorenzo | 6 | 2 | 1 | 3 | 7:6 | 1 | 7 |
| 4 | 12 de Octubre | 6 | 1 | 3 | 2 | 3:5 | -2 | 6 |
Group B
| Pl | W | D | L | Diff | Pts | |||
| 1 | Independiente | 6 | 4 | 2 | 0 | 11:5 | 6 | 14 |
| 2 | Montevideo City | 6 | 3 | 2 | 1 | 15:7 | 8 | 11 |
| 3 | Bahia | 6 | 2 | 2 | 2 | 11:8 | 3 | 8 |
| 4 | Guabira | 6 | 0 | 0 | 6 | 1:18 | -17 | 0 |
Group C
| Pl | W | D | L | Diff | Pts | |||
| 1 | Arsenal Sarandi | 6 | 3 | 2 | 1 | 9:4 | 5 | 11 |
| 2 | Ceara | 6 | 2 | 3 | 1 | 5:2 | 3 | 9 |
| 3 | Bolivar | 6 | 1 | 3 | 2 | 5:8 | -3 | 6 |
| 4 | Wilstermann | 6 | 1 | 2 | 3 | 5:10 | -5 | 5 |
Group D
| Pl | W | D | L | Diff | Pts | |||
| 1 | Athletico-PR | 6 | 5 | 0 | 1 | 8:1 | 7 | 15 |
| 2 | FBC Melgar | 6 | 3 | 1 | 2 | 7:5 | 2 | 10 |
| 3 | Aucas | 6 | 2 | 0 | 4 | 7:11 | -4 | 6 |
| 4 | Metropolitanos | 6 | 1 | 1 | 4 | 5:10 | -5 | 4 |
Group E
| Pl | W | D | L | Diff | Pts | |||
| 1 | Penarol | 6 | 4 | 1 | 1 | 15:3 | 12 | 13 |
| 2 | Corinthians | 6 | 3 | 1 | 2 | 12:6 | 6 | 10 |
| 3 | River Plate | 6 | 3 | 1 | 2 | 6:10 | -4 | 10 |
| 4 | Sport Huancayo | 6 | 0 | 1 | 5 | 3:17 | -14 | 1 |
Group F
| Pl | W | D | L | Diff | Pts | |||
| 1 | Libertad Asuncion | 6 | 4 | 1 | 1 | 9:4 | 5 | 13 |
| 2 | Atletico GO | 6 | 2 | 4 | 0 | 4:2 | 2 | 10 |
| 3 | Newells Old Boys | 6 | 2 | 2 | 2 | 6:6 | 0 | 8 |
| 4 | Palestino | 6 | 0 | 1 | 5 | 2:9 | -7 | 1 |
Group G
| Pl | W | D | L | Diff | Pts | |||
| 1 | Bragantino | 6 | 4 | 0 | 2 | 7:6 | 1 | 12 |
| 2 | Emelec | 6 | 3 | 1 | 2 | 9:8 | 1 | 10 |
| 3 | Talleres Cordoba | 6 | 2 | 2 | 2 | 7:5 | 2 | 8 |
| 4 | Deportes Tolima | 6 | 0 | 3 | 3 | 4:8 | -4 | 3 |
Group H
| Pl | W | D | L | Diff | Pts | |||
| 1 | Gremio | 6 | 5 | 1 | 0 | 21:5 | 16 | 16 |
| 2 | Lanus | 6 | 3 | 1 | 2 | 8:6 | 2 | 10 |
| 3 | La Equidad | 6 | 2 | 1 | 3 | 6:9 | -3 | 7 |
| 4 | Aragua | 6 | 0 | 1 | 5 | 4:19 | -15 | 1 |
Promotion ~ Copa Sudamericana (Play Offs: )
2021 Play Offs
1/8-finals
| 1 | Penarol (4) | Nacional (11) | 0 : 1, 2 : 1 |
| 2 | Arsenal Sarandi (8) | Sporting Cristal (16) | 1 : 1, 1 : 2 |
| 3 | Athletico-PR (2) | America De Cali (15) | 4 : 1, 1 : 0 |
| 4 | Gremio (1) | LDU Quito (10) | 1 : 2, 1 : 0 |
| 5 | Bragantino (6) | Ind. del Valle (14) | 1 : 1, 2 : 0 |
| 6 | Rosario Central (7) | Dep. Tachira (9) | 1 : 0, 2 : 2 |
| 7 | Independiente (3) | Santos (13) | 1 : 1, 0 : 1 |
| 8 | Libertad Asuncion (5) | Junior (12) | 0 : 1, 4 : 3 |
Quarter-finals
| 1 | Penarol (4) | Sporting Cristal (16) | 1 : 0, 3 : 1 |
| 2 | Athletico-PR (2) | LDU Quito (10) | 4 : 2, 0 : 1 |
| 3 | Bragantino (6) | Rosario Central (7) | 1 : 0, 4 : 3 |
| 4 | Santos (13) | Libertad Asuncion (5) | 0 : 1, 2 : 1 |
Semi-finals
| 1 | Penarol (4) | Athletico-PR (2) | 0 : 2, 1 : 2 |
| 2 | Bragantino (6) | Libertad Asuncion (5) | 3 : 1, 2 : 0 |
Final
| 1 | Athletico-PR (2) | Bragantino (6) | 1 : 0 |
2021 Qualification
Final
| 1 | Macara | Emelec | 0 : 2, 2 : 2 |
| 2 | 12 de Octubre | Nacional Asuncion | 1 : 0, 0 : 0 |
| 3 | Deportes Tolima | Dep. Cali | 0 : 0, 3 : 0 |
| 4 | Antofagasta | Huachipato | 0 : 3, 0 : 1 |
| 5 | Guabira | Nacional Potosi | 2 : 1, 4 : 1 |
| 6 | Wilstermann | Palmaflor | 2 : 1, 2 : 1 |
| 7 | Aragua | Mineros | 2 : 1, 0 : 1 |
| 8 | Cajamarca | Sport Huancayo | 0 : 4, 0 : 1 |
| 9 | Aucas | Guayaquil City | 3 : 0, 2 : 1 |
| 10 | Guairena | River Plate | 2 : 4, 1 : 2 |
| 11 | Metropolitanos | Puerto Cabello | 1 : 0, 2 : 0 |
| 12 | Cobresal | Palestino | 1 : 2, 0 : 0 |
| 13 | La Equidad | Dep. Pasto | 2 : 0, 1 : 2 |
| 14 | Carlos Mannucci | FBC Melgar | 2 : 3, 1 : 2 |
| 15 | Montevideo City | Fenix | 2 : 0, 0 : 0 |
| 16 | Cerro Largo | Penarol | 1 : 4, 2 : 2 |
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