2022
1/64-finals
1/32-finals
| 1 | Atenas | Mar De Fondo | 0 : 1 |
| 2 | Bye | Cerrito | |
| 3 | Uruguay Montevideo | Palermo de Rocha | 2 : 1 |
| 4 | Bye | Montevideo City | |
| 5 | Rocha | Huracan Buceo | 2 : 1 |
| 6 | Bye | Rentistas | |
| 7 | Progreso | Bye | |
| 8 | Bye | Danubio | |
| 9 | Racing Montevideo | Huracan Paysandu | 1 : 0 |
| 10 | Bye | Defensor Sp. | |
| 11 | Juventud Colonia | Bye | |
| 12 | Bye | River Plate | |
| 13 | Central Esp. | Artigas | 2 : 1 |
| 14 | Bye | Liverpool M. | |
| 15 | Universitario Salto | Paysandu FC | 1 : 0 |
| 16 | Bye | Wanderers | |
| 17 | Durazno | Boquita | 2 : 1 |
| 18 | Bye | Plaza Colonia | |
| 19 | Quilmes | Deportivo Colonia | 1 : 2 |
| 20 | Bye | Cerro Largo | |
| 21 | Colon | Los Halcones | 3 : 1 |
| 22 | Bye | Penarol | |
| 23 | Central San Jose | Bye | |
| 24 | Bye | Boston River | |
| 25 | Rampla Juniors | Rio Negro | 2 : 1 |
| 26 | Bye | Maldonado | |
| 27 | Miramar | Bye | |
| 28 | Bye | Nacional | |
| 29 | Juventud | Universal San Jose | 1 : 0 |
| 30 | Bye | Albion | |
| 31 | La Luz | Deportivo Italiano | 2 : 1 |
| 32 | Bye | Fenix |
1/16-finals
| 1 | Mar De Fondo | Cerrito | 0 : 1 |
| 2 | Uruguay Montevideo | Montevideo City | 2 : 4 |
| 3 | Rocha | Rentistas | 0 : 3 |
| 4 | Progreso | Danubio | 3 : 2 |
| 5 | Racing Montevideo | Defensor Sp. | 0 : 1 |
| 6 | Juventud Colonia | River Plate | 1 : 2 |
| 7 | Central Esp. | Liverpool M. | 1 : 2 |
| 8 | Universitario Salto | Wanderers | 1 : 3 |
| 9 | Durazno | Plaza Colonia | 1 : 3 |
| 10 | Deportivo Colonia | Cerro Largo | 0 : 2 |
| 11 | Colon | Penarol | 0 : 2 |
| 12 | Central San Jose | Boston River | 0 : 2 |
| 13 | Rampla Juniors | Maldonado | 2 : 1 |
| 14 | Miramar | Nacional | 0 : 1 |
| 15 | Juventud | Albion | 0 : 1 |
| 16 | La Luz | Fenix | 2 : 1 |
1/8-finals
| 1 | Cerrito | Montevideo City | 0 : 1 |
| 2 | Rentistas | Progreso | 0 : 3 |
| 3 | Defensor Sp. | River Plate | 2 : 0 |
| 4 | Liverpool M. | Wanderers | 4 : 0 |
| 5 | Plaza Colonia | Cerro Largo | 1 : 0 |
| 6 | Penarol | Boston River | 1 : 0 |
| 7 | Rampla Juniors | Nacional | 3 : 0 |
| 8 | Albion | La Luz | 2 : 3 |
Quarter-finals
| 1 | Montevideo City | Progreso | 1 : 2 |
| 2 | Defensor Sp. | Liverpool M. | 3 : 0 |
| 3 | Plaza Colonia | Penarol | 0 : 1 |
| 4 | Rampla Juniors | La Luz | 2 : 3 |
Semi-finals
| 1 | Progreso | Defensor Sp. | 1 : 3, 1 : 1 |
| 2 | Penarol | La Luz | 0 : 2, 1 : 0 |
Final
| 1 | Defensor Sp. | La Luz | 1 : 0 |
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