2021 Main
| Pl | W | D | L | Diff | Pts | |||
| 1 | Shakhtyor Soligorsk | 30 | 24 | 3 | 3 | 62:18 | 44 | 75 |
| 2 | BATE | 30 | 19 | 8 | 3 | 61:27 | 34 | 65 |
| 3 | Din. Minsk | 30 | 19 | 5 | 6 | 55:20 | 35 | 62 |
| 4 | FC Gomel | 30 | 17 | 8 | 5 | 57:23 | 34 | 59 |
| 5 | Rukh Brest | 30 | 16 | 10 | 4 | 52:28 | 24 | 58 |
| 6 | Dynamo Brest | 30 | 8 | 14 | 8 | 32:32 | 0 | 38 |
| 7 | Vitebsk | 30 | 9 | 10 | 11 | 37:41 | -4 | 37 |
| 8 | Zhodino | 30 | 10 | 6 | 14 | 38:43 | -5 | 36 |
| 9 | Slutsk | 30 | 9 | 8 | 13 | 36:44 | -8 | 35 |
| 10 | Isloch | 30 | 9 | 7 | 14 | 38:47 | -9 | 34 |
| 11 | Neman | 30 | 9 | 7 | 14 | 36:36 | 0 | 34 |
| 12 | FC Minsk | 30 | 8 | 9 | 13 | 32:52 | -20 | 33 |
| 13 | Energetik-BGU | 30 | 8 | 9 | 13 | 35:42 | -7 | 33 |
| 14 | Slavia Mozyr | 30 | 8 | 8 | 14 | 42:50 | -8 | 32 |
| 15 | Smorgon | 30 | 4 | 9 | 17 | 26:66 | -40 | 21 |
| 16 | Sputnik | 30 | 2 | 1 | 27 | 12:82 | -70 | 7 |
Promotion ~ Champions League (Qualification: )
Promotion ~ Europa Conference League (Qualification: )
Vysshaya Liga (Relegation)
Relegation ~ Pershaya Liga
2021 Relegation
Final
| 1 | Slavia Mozyr | Krumkachy | 0 : 0, 1 : 0 |
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