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Promotion ~ Gamma Ethniki ~ Promotion Play~offs
Relegation
Promotion ~ Super League 2
2021/22 Main
| Pl | W | D | L | Diff | Pts | |||
| 1 | Panachaiki | 24 | 18 | 2 | 4 | 53:16 | 37 | 56 |
| 2 | Tilikratis L | 24 | 16 | 4 | 4 | 44:17 | 27 | 52 |
| 3 | Diavolitsi | 24 | 14 | 5 | 5 | 40:23 | 17 | 47 |
| 4 | Acheron Kanalaki | 24 | 11 | 7 | 6 | 33:19 | 14 | 40 |
| 5 | Panagriniakos | 24 | 11 | 6 | 7 | 28:21 | 7 | 39 |
| 6 | Nafpaktiakos | 24 | 11 | 6 | 7 | 30:19 | 11 | 39 |
| 7 | Aias Gastounis | 24 | 12 | 3 | 9 | 37:30 | 7 | 39 |
| 8 | Diagoras Vrachneikon | 24 | 10 | 5 | 9 | 30:24 | 6 | 35 |
| 9 | Ethnikos Skoulikadou | 24 | 9 | 5 | 10 | 20:26 | -6 | 32 |
| 10 | PAO Varda | 24 | 6 | 4 | 14 | 22:29 | -7 | 22 |
| 11 | Panegialios FC | 24 | 4 | 7 | 13 | 18:31 | -13 | 19 |
| 12 | Anagennisi Arta | 24 | 6 | 1 | 17 | 19:46 | -27 | 19 |
| 13 | Amvrakikos Loutrou | 24 | 0 | 1 | 23 | 2:75 | -73 | 1 |
Promotion ~ Gamma Ethniki ~ Promotion Play~offs
Relegation
2021/22 Promotion - Play Offs
| Pl | W | D | L | Diff | Pts | |||
| 1 | Panachaiki | 6 | 5 | 0 | 1 | 11:5 | 6 | 15 |
| 2 | Proodeftiki | 6 | 3 | 1 | 2 | 8:3 | 5 | 10 |
| 3 | A. Asteras | 6 | 3 | 1 | 2 | 9:6 | 3 | 10 |
| 4 | Makedonikos | 6 | 2 | 3 | 1 | 5:4 | 1 | 9 |
| 5 | Ilioupoli | 6 | 2 | 1 | 3 | 8:7 | 1 | 7 |
| 6 | Rouf FC | 6 | 2 | 1 | 3 | 7:9 | -2 | 7 |
| 7 | Iraklis Larissa | 6 | 0 | 1 | 5 | 4:18 | -14 | 1 |
Promotion ~ Super League 2
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