2021 Main
| Pl | W | D | L | Diff | Pts | |||
| 1 | Adelaide Comets | 22 | 12 | 7 | 3 | 40:26 | 14 | 43 |
| 2 | Adelaide City | 22 | 11 | 8 | 3 | 40:20 | 20 | 41 |
| 3 | Campbelltown City | 22 | 10 | 5 | 7 | 41:28 | 13 | 35 |
| 4 | NE Metrostars | 22 | 9 | 6 | 7 | 36:26 | 10 | 33 |
| 5 | Sturt Lions | 22 | 9 | 6 | 7 | 34:34 | 0 | 33 |
| 6 | South Adelaide | 22 | 9 | 5 | 8 | 38:36 | 2 | 32 |
| 7 | Adelaide Olympic | 22 | 6 | 11 | 5 | 37:33 | 4 | 29 |
| 8 | Croydon Kings | 22 | 7 | 8 | 7 | 29:30 | -1 | 29 |
| 9 | Adelaide U21 | 22 | 7 | 4 | 11 | 34:45 | -11 | 25 |
| 10 | Cumberland Utd | 22 | 7 | 4 | 11 | 28:45 | -17 | 25 |
| 11 | Adelaide Raiders | 22 | 6 | 4 | 12 | 33:48 | -15 | 22 |
| 12 | Blue Eagles | 22 | 3 | 4 | 15 | 27:46 | -19 | 13 |
Promotion ~ NPL ACT (Final Stage: )
Promotion ~ NPL South Australian (Play Offs: )
Relegation
2021 Play Offs
1/8-finals
| 1 | Adelaide City | Adelaide Comets | 3 : 1, 0 : 1 |
| 5 | Adelaide Comets | Bye | |
| 7 | NE Metrostars | Sturt Lions | 0 : 1 |
| 8 | Campbelltown City | South Adelaide | 1 : 3 |
Quarter-finals
| 1 | Adelaide City | Bye | |
| 3 | Adelaide Comets | Bye | |
| 4 | Sturt Lions | South Adelaide | 3 : 2 |
Semi-finals
| 1 | Adelaide City | Bye | |
| 2 | Adelaide Comets | Sturt Lions | 1 : 0 |
Final
| 1 | Adelaide City | Adelaide Comets | 1 : 0 |
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